When there’s stress,
use ZACTRAN® (gamithromycin).

Bovine Respiratory Disease, or BRD, is a serious condition for calves and has big downsides for both beef and dairy producers. In fact, it’s the number one cause of mortality in weaned calves.11 - Heifer Calf Health and Management Practices on U.S. Dairy Operations, 2007. USDA APHIS. Published January 2010. And death can happen within a couple of days.

Even calves that recover from BRD can suffer lasting effects, including lower weight gain, lower-quality carcass and lower lifetime milk production. And that can add up. In fact, it’s estimated that BRD costs producers up to $900 million each year.22 - Science Daily. Bovine Respiratory Disease: New Research to Tackle Major Concern for Cattle Industry. http://www.sciencedaily.com/releases/2010/03/100305112203.htm. Accessed March 2010.

But you can manage the risk with ZACTRAN. A single administration provides 10-day BRD treatment and control.

A potent combination of 6 factors makes ZACTRAN the smart choice.

1.

Pathogen Susceptibility

BRD often involves more than one bacterial pathogen, including Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis. These pathogens are sensitive to gamithromycin, the active ingredient in ZACTRAN.

And unlike some antimicrobials, ZACTRAN is labeled to treat all four of these major BRD pathogens.

2.

Speed to Action is Important

When it’s BRD, you want antimicrobials to get to work quickly to minimize lung damage. With ZACTRAN, you should start to see improvement in sick cattle the next day.i

Cattle treated with ZACTRAN responded within 24 hours, had lower temperatures, were more alert and breathing easier.i

iSifferman RL, Wolff WA, Holste JE, et al. Field efficacy evaluation of
gamithromycin for treatment of bovine respiratory disease in cattle at feedlots.
Intern J Appl Res Vet Med. 2011;9(2):171-180.

3.

Gets to the Site of Infection

The pulmonary epithelial lining fluid (PELF) covers the surfaces in the lung and is the primary site of BRD.ii ZACTRAN travels with immune cells to the site of infection – the PELF.iii And it gets there in just 30 minutes.iii*

*Clinical relevance has not been determined.

iiGiguere S, Tessman RK. Rational dosing of antimicrobial agents for bovine
respiratory disease: The use of plasma versus tissue concentrations in
predicting efficacy. Intern J Appl Res Vet Med. 2011;9(4):342-355.

iiiGiguere S, Huang R, Malinski TJ, et al. Disposition of gamithromycin in
plasma, pulmonary epithelial lining fluid, bronchoalveolar cells and lung
tissue in cattle. Am J Vet Res. 2011;72(3):326-330.

4.

Staying Power in a Single Dose

The animal’s immune system needs time to fight off BRD. ZACTRAN gives them that time with 10 days above MIC90 in the lung and PELF.*iii

*Clinical relevance has not been determined.

iiiGiguere S, Huang R, Malinski TJ, et al. Disposition of gamithromycin in
plasma, pulmonary epithelial lining fluid, bronchoalveolar cells and lung tissue
in cattle. Am J Vet Res. 2011;72(3):326-330.

5.

Safety and Ease of Use

Accidental needle sticks can and do happen. You want a product that offers minimal risk while also minimizing the need to break up doses among multiple sites. ZACTRAN can be used with automatic syringes and offers a low dose volume. Bonus! It has excellent syringeability even in freezing temperatures.iv

ivData on file at Merial.

6.

Saves You Money

Economically managing BRD is critical to maintaining a profitable herd. When you compare costs per dose and add in all the other benefits, you’ll find ZACTRAN is a great value.

Compare and see for yourself.

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Manage the risk of BRD in beef and dairy calves with ZACTRAN. A single, economical administration provides effective 10-day BRD treatment and control.33 - ZACTRAN product label. Use our calculator to compare costs with your current treatment.

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Prevention. Control. Treatment.

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