When there’s stress,
use ZACTRAN® (gamithromycin).

Bovine Respiratory Disease, or BRD, is a serious condition for calves and has big downsides for both beef and dairy producers. In fact, it’s the number one cause of mortality in weaned calves.11 - Heifer Calf Health and Management Practices on U.S. Dairy Operations, 2007. USDA APHIS. Published January 2010. And death can happen within a couple of days.

Even calves that recover from BRD can suffer lasting effects, including lower weight gain, lower-quality carcass and lower lifetime milk production. And that can add up. In fact, it’s estimated that BRD costs producers up to $900 million each year.22 - Science Daily. Bovine Respiratory Disease: New Research to Tackle Major Concern for Cattle Industry. http://www.sciencedaily.com/releases/2010/03/100305112203.htm. Accessed March 2010.

But you can manage the risk with ZACTRAN. A single administration provides 10-day BRD treatment and control.

24-Hour Rapid Response

In field trials with clinically ill cattle, those treated with ZACTRAN showed a visible improvement within 24 hours.44 - Sifferman RL, Wolff WA, Holste JE, et al. Field efficacy evaluation of gamithromycin for treatment of bovine respiratory disease in cattle at feedlots. Intern J Appl Res Vet Med. 2011;9(2):171-180. Of the cattle with rectal temperatures higher than 104 °F, more than 75 percent of ZACTRAN-treated cattle had reduced temperatures within 24 hours.55 - Data on file at Merial.

24-Hour Rapid Response

In field trials with clinically ill cattle, those treated with ZACTRAN showed a visible improvement within 24 hours.44 - Sifferman RL, Wolff WA, Holste JE, et al. Field efficacy evaluation of gamithromycin for treatment of bovine respiratory disease in cattle at feedlots. Intern J Appl Res Vet Med. 2011;9(2):171-180. Of the cattle with rectal temperatures higher than 104 °F, more than 75 percent of ZACTRAN-treated cattle had reduced temperatures within 24 hours.55 - Data on file at Merial.

10-Day Treatment & Control

ZACTRAN is approved for treatment of BRD associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis.33 - ZACTRAN product label. In field trials, the majority of clinically ill cattle treated with ZACTRAN recovered and stayed healthy for the 10-day study.33 - ZACTRAN product label.

In BRD control field trials, the majority of lightweight, long-haul, high-risk cattle treated with ZACTRAN stayed healthy for the 10-day study.33 - ZACTRAN product label.

In safety studies, no clinically significant adverse drug-related effects were observed.33 - ZACTRAN product label.

10-Day Treatment & Control

ZACTRAN is approved for treatment of BRD associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis.33 - ZACTRAN product label. In field trials, the majority of clinically ill cattle treated with ZACTRAN recovered and stayed healthy for the 10-day study.33 - ZACTRAN product label.

In BRD control field trials, the majority of lightweight, long-haul, high-risk cattle treated with ZACTRAN stayed healthy for the 10-day study.33 - ZACTRAN product label.

In safety studies, no clinically significant adverse drug-related effects were observed.33 - ZACTRAN product label.

1 Easy, Economical Injection

ZACTRAN is competitively priced to be the choice for frontline BRD control for stressed calves on arrival. Plus, ZACTRAN is designed to fit easily into the way you work cattle.

• Low dose volume – administered subcutaneously in the neck at 2 mL/110 lbs.

• Highly syringable – even at sub-freezing temperatures.88 - Data on file at Merial.

• Ready to use – available in 100 mL, 250 mL and 500 mL bottle sizes; 250 mL and 500 mL bottles are enclosed in individual plastic bottle protectors.

1 Easy, Economical Injection

ZACTRAN is competitively priced to be the choice for frontline BRD control for stressed calves on arrival. Plus, ZACTRAN is designed to fit easily into the way you work cattle.

• Low dose volume – administered subcutaneously in the neck at 2 mL/110 lbs.

• Highly syringable – even at sub-freezing temperatures.88 - Data on file at Merial.

• Ready to use – available in 100 mL, 250 mL and 500 mL bottle sizes; 250 mL and 500 mL bottles are enclosed in individual plastic bottle protectors.

20 Days in the Lungs

ZACTRAN remains at high levels in the lungs for an extended period. ZACTRAN reaches MIC90 in lung tissues within 30 minutes, reaching peak concentration in 12 hours, then remained in the lungs 20 or more days, the last point in the study in which it was measured.*6,76 - Giguere S, Huang R, Malinski TJ, et al. Disposition of gamithromycin in plasma, pulmonary epithelial lining fluid, bronchoalveolar cells and lung tissue in cattle. Am J Vet Res. 2011;72(3):326-330.7 - Huang RA, Letendre LT, Banav N, et al. Pharmacokinetics of gamithromycin in cattle with comparison of plasma and lung tissue concentrations and plasma antibacterial activity. J Vet Pharmacol Ther. 2010;33(3):227-237.

*The correlation between pharmacokinetic data and clinical relevance is unknown.

20 Days in the Lungs

ZACTRAN remains at high levels in the lungs for an extended period. ZACTRAN reaches MIC90 in lung tissues within 30 minutes, reaching peak concentration in 12 hours, then remained in the lungs 20 or more days, the last point in the study in which it was measured.*6,76 - Giguere S, Huang R, Malinski TJ, et al. Disposition of gamithromycin in plasma, pulmonary epithelial lining fluid, bronchoalveolar cells and lung tissue in cattle. Am J Vet Res. 2011;72(3):326-330.7 - Huang RA, Letendre LT, Banav N, et al. Pharmacokinetics of gamithromycin in cattle with comparison of plasma and lung tissue concentrations and plasma antibacterial activity. J Vet Pharmacol Ther. 2010;33(3):227-237.

*The correlation between pharmacokinetic data and clinical relevance is unknown.

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Manage the risk of BRD in beef and dairy calves with ZACTRAN. A single, economical administration provides effective 10-day BRD treatment and control.33 - ZACTRAN product label. Use our calculator to compare costs with your current treatment.

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