BRD is waiting for
an opportunity.

Bovine Respiratory Disease (BRD) is any infection of the respiratory tract. While cattle normally carry BRD-causing pathogens in their system, including Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis, it isn’t until the immune system is compromised by stress that these pathogens can invade the lungs.

Weaning, shipping, commingling and dehorning all cause stress. But even seemingly minor environmental events, like changes in temperature, dust, inadequate ventilation and moisture, can be a factor.

As the bacteria reproduce, the immune system sends disease-fighting cells to combat the growing infection. The bacteria fight back by releasing endotoxins that cause inflammation in the lung lining. This inflammation damages the lungs, and the signs of pneumonia quickly develop, including fever, depression, lowered head, lethargy, not eating, nasal discharge, diarrhea, shallow breathing and coughing.

Left untreated, BRD can cause poor performance and even death. ZACTRAN® (gamithromycin) provides a response within 24 hours and 10-day treatment and control with a single administration.1-31 - Heifer Calf Health and Management Practices on U.S. Dairy Operations, 2007. USDA APHIS. Published January 2010.2 - Science Daily. Bovine Respiratory Disease: New Research to Tackle Major Concern for Cattle Industry. http://www.sciencedaily.com/releases/2010/03/100305112203.htm. Accessed March 2010.3 - ZACTRAN product label.


BRD bacteria reside in the upper respiratory tract of even healthy animals.

Viral infections or stress from shipping, weaning or other events allow bacteria to accumulate in the lungs.

Bacteria colonize and proliferate, causing inflammation, leading to BRD.

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Manage the risk of BRD in beef and dairy calves with ZACTRAN. A single, economical administration provides effective 10-day BRD treatment and control.33 - ZACTRAN product label. Use our calculator to compare costs with your current treatment.

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