Treating and controlling BRD with ZACTRAN® (gamithromycin).

ZACTRAN is a novel subclass of macrolide with a structural difference.55 - Data on file at Merial. It is indicated for BRD treatment and control in cattle.33 - ZACTRAN product label. The active ingredient in ZACTRAN, gamithromycin, is rapidly absorbed and extensively distributed in lung tissue where it persists in high levels for an extended period.6,76 - Giguere S, Huang R, Malinski TJ, et al. Disposition of gamithromycin in plasma, pulmonary epithelial lining fluid, bronchoalveolar cells and lung tissue in cattle. Am J Vet Res. 2011;72(3):326-330.7 - Huang RA, Letendre LT, Banav N, et al. Pharmacokinetics of gamithromycin in cattle with comparison of plasma and lung tissue concentrations and plasma antibacterial activity. J Vet Pharmacol Ther. 2010;33(3):227-237.

*Clinical relevance has not been determined.

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ZACTRAN Is Rapidly Absorbed

  • ≥95 percent bioavailable following subcutaneous (SC) injection.77 - Huang RA, Letendre LT, Banav N, et al. Pharmacokinetics of gamithromycin in cattle with comparison of plasma and lung tissue concentrations and plasma antibacterial activity. J Vet Pharmacol Ther. 2010;33(3):227-237.
  • Rapidly absorbed and extensively distributed throughout the lungs.3,73 - ZACTRAN product label.7 - Huang RA, Letendre LT, Banav N, et al. Pharmacokinetics of gamithromycin in cattle with comparison of plasma and lung tissue concentrations and plasma antibacterial activity. J Vet Pharmacol Ther. 2010;33(3):227-237.
  • Reaches levels above MIC90 in lung tissue within 30 minutes.66 - Giguere S, Huang R, Malinski TJ, et al. Disposition of gamithromycin in plasma, pulmonary epithelial lining fluid, bronchoalveolar cells and lung tissue in cattle. Am J Vet Res. 2011;72(3):326-330.
  • Remains at high concentrations above MIC90 in lung tissue and bronchoalveolar lavage (BAL) cells for 10 days.66 - Giguere S, Huang R, Malinski TJ, et al. Disposition of gamithromycin in plasma, pulmonary epithelial lining fluid, bronchoalveolar cells and lung tissue in cattle. Am J Vet Res. 2011;72(3):326-330.
  • Exhibits both bactericidal and bacteriostatic activity – killing bacteria and stopping its growth.33 - ZACTRAN product label.

*Clinical relevance has not been determined.

ZACTRAN Is Effective

ZACTRAN compares favorably to DRAXXIN® (tulathromycin) and EXCEDE® (ceftiofur crystalline free acid) for control of BRD.9,109 - Data on file at Merial.10 - Amrine D, White B, Goehl D, Sweiger SH, Nosky B, Tessman RK. Comparisons of Metaphylactic Treatments of ZACTRAN® (gamithromyicn) vs. Excede® (ceftiofur crystalline free acid) in High Risk Stocker Calves. Intern J Appl Res Vet Med. 2014;12(3):221-228.

Zactran Chart Information

** No significant difference in morbidity was seen at the Nebraska site. However, a higher first-pull rate was found with ZACTRAN at the Kansas site (P<0.01). No statistical difference seen in other parameters. Significance noted if P≤0.05.

Zactran Chart Information

*Statistically significant treatment difference (P≤0.05).

  • In field trials, cattle treated with ZACTRAN showed a rapid response and significant improvement in BRD clinical signs within 24 hours after treatment.44 - Sifferman RL, Wolff WA, Holste JE, et al. Field efficacy evaluation of gamithromycin for treatment of bovine respiratory disease in cattle at feedlots. Intern J Appl Res Vet Med. 2011;9(2):171-180.
  • In field trials, ZACTRAN provided 10-day treatment and control of BRD from a single dose.1111 - Lechtenberg K, Daniels CS, Royer GC, et al. Field efficacy study of gamithromycin for the control of bovine respiratory disease in cattle at high risk of developing the disease. Intern J Appl Res Vet Med. 2011;9(2):189-197.

Indications33 - ZACTRAN product label.

  • ZACTRAN is indicated for the treatment of BRD associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis in beef and non-lactating dairy cattle.
  • ZACTRAN is indicated for the control of respiratory disease in beef and non-lactating dairy cattle at high risk of developing BRD associated with M. haemolytica and P. multocida.

ZACTRAN is Easy and Economical

  • ZACTRAN is competitively priced for treatment or control of BRD in stressed cattle on arrival and can help improve clinic profitability.
  • ZACTRAN offers a low dose volume (2 mL/110 lbs.) and is administered subcutaneously in the easily accessible neck area.33 - ZACTRAN product label.
  • ZACTRAN is available only by prescription.
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Manage the risk of BRD in beef and dairy calves with ZACTRAN. A single, economical administration provides effective 10-day BRD treatment and control.33 - ZACTRAN product label. Use our calculator to compare costs with your current treatment.

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